Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation
نویسندگان
چکیده
Background: Lithium has been reported in some, but not all, studies to be associated with reduced suicide risk. Methods: Intention-to-treat, high-dimensional propensity score-matched cohort study of one-year suicide mortality in Veterans Health Administration patients (n = 21,194/treatment) initiating lithium or valproate from 1999-2008. One-year suicide mortality was examined among all patients initiating lithium or valproate (intention-totreat analysis) who were matched on 934 propensity score covariates ranging from demographics, diagnoses, inpatient and outpatient encounters, current and recent medications, and indicators of recent suicidal behavior. Results: No significant difference in suicide was observed over 0-365 days in the primary intent-to-treat analysis (lithium/valproate conditional odds ratio (cOR) = 1.22, 95% CI 0.82, 1.81; p = 0.32), when individuals were still receiving their initial lithium or valproate treatment (cOR = 0.86, 0.46, 1.61; p = 0.63) or after such treatment had been discontinued/modified (OR = 1.51, 95% CI 0.91, 2.50; p = 0.11). Significantly increased suicide risks in the first 0-180 days of follow-up were observed in secondary analyses of
منابع مشابه
Mortality associated with lithium and valproate treatment of US Veterans Health Administration patients with mental disorders.
BackgroundThe mood stabilisers lithium and valproate might plausibly have differing associations with mortality because of differing effects on mental health and various physiological indicators.AimsTo assess associations between lithium, valproate and non-suicide mortality.MethodIntention-to-treat, propensity score-matched cohort study.ResultsLithium was associated with significantly reduced n...
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The purpose of this study was to compare the effectiveness of three common mood stabilizing drugs, Lithium, Carbamazepine and Valproate in the treatment of acute mania Of the 114 patients who participated in this study, 60 were treated with Lithium, 30 with Carbamazepine and 24 with Valproate. This study was a prospective and double blind study. The patients were assessed by GAF Scale and a man...
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OBJECTIVE Conclusions regarding lithium's antisuicidal effect for bipolar disorder have been limited due to nonrepresentative subjects and potential confounding factors, including varying severity of illness. Findings regarding the effect of valproate, the most common alternative to lithium, are inconsistent for suicidal behavior. This study investigated the associations of these two drugs with...
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